Cytokine and hormone status of women of reproductive age with pulmonary tuberculosis

Objective. To study the levels of cytokines (γ-interferon, tumor necrosis factor α (TNF-α)) and hormones (cortisol, prolactin, estradiol, progesterone, testosterone) in blood serum women reproductive age with pulmonary tuberculosis (TB). Materials methods. We studied γ-interferon, α, cortisol, testosterone 18-45 years old newly diagnosed TB (n = 47) compared same indices without no previous 35). Results. Women had higher cortisol (cutoff point, 196.1 nmol/L, AUC 0.75, Se 85.1 %, Sp 70.6 %) prolactin 486, 1 mEU/L, 0.69, 59.6%, 73.5%) lower progesterone point 3.9 0.71, 73.9%, 64.7%) than TB. The γ-interferon TNF-α showed less diagnostic significance parameters, there was a slight increase both Conclusion. Changes cytokine-hormone status can reflect mechanisms anti-infective defense be consequence development disease.